Método:Īs pesquisas incluíram as bases de dados PubMed/MEDLINE, Web of Science, Science Direct e SciELO, além da literatura cinza. Objetivo:Įste artigo tem como objetivo revisar a literatura atual sobre os principais tipos de células-tronco com potencial para aplicação em terapia celular para perda auditiva sensorioneural, os experimentos mais relevantes já realizados em animais, bem como os avanços obtidos recentemente nessa área. Contudo, como não há tratamento que restabeleça a função auditiva, as terapias regenerativas utilizando células-tronco representam uma alternativa promissora. Assim, os danos a esses tipos celulares são permanentes e levam à perda auditiva. Nos mamíferos, as células ciliadas e os neurônios auditivos não apresentam capacidade regenerativa. Conclusion:Īdvances have been more prominent in cases of auditory neuropathy, since partial improvement of auditory nerve conditions through cell-based therapy may increase the number of patients who can successfully receive cochlear implants.Ĭellular therapy Stem cells Hair cells Auditory neurons When transplanted into the cochlea of animals with hearing loss, auditory restoration has been documented to date only in deafferented animals. Remarkably, these differentiated cells are able to interact with hair cells and auditory neurons of cochlear explants through formation of new synapses. Results:ĭifferentiation of stem cells into hair cells and auditory neurons has a high success rate, reaching up to 82% for the first and 100% for the latter. The research was conducted independently by three researchers. Additionally, the main terms were combined with the following secondary terms: 'mesenchymal', 'iPS', 'inner ear', 'auditory'. Search strategy included the following main terms: 'stem cells', 'hair cells' and 'auditory neurons'. Research included the databases PubMed/MEDLINE, Web of Science, Science Direct and SciELO, as well as gray literature. This article aims to review the current literature about the main types of stem cells with potential for application in cell therapy for sensorineural hearing loss, the most relevant experiments already performed in animals, as well as the advances that have been recently made in the field. Regenerative therapies using stem cells represent a promising alternative. However, there is no treatment that re-establishes auditory function. Hence, damage to these cell types is permanent and leads to hearing loss. Mammalian hair cells and auditory neurons do not show regenerative capacity.

Universidade de São Paulo, Instituto de Biociências, Departamento de Genética e Biologia Evolutiva, São Paulo, SP, Brazil

Universidade de São Paulo, Faculdade de Medicina, Laboratório de Otorrinolaringologia/LIM32, São Paulo, SP, Brazil Rodrigo Salazar-Silva Universidade de São Paulo, Faculdade de Medicina, Laboratório de Otorrinolaringologia/LIM32, São Paulo, SP, Brazil Jeanne Oiticica Universidade de São Paulo, Instituto de Biociências, Departamento de Genética e Biologia Evolutiva, São Paulo, SP, Brazil Ana Carla Batissoco Universidade de São Paulo, Instituto de Biociências, Departamento de Genética e Biologia Evolutiva, São Paulo, SP, Brazil Regina Célia Mingroni Netto Universidade de São Paulo, Instituto de Biociências, Departamento de Genética e Biologia Evolutiva, São Paulo, SP, Brazil Dayane Bernardino da Cruz

Stem cell treatment for hearing loss